Welcome to the Brown Lab

Our Research

The Brown Lab focuses on exploring the nexus of pluripotent stem cell (PSC) biology and immunology. We are currently investigating the mechanisms underpinning the immune response to autologous and allogeneic PSC-derived cell therapies. Using transplantation immunology and genomics-based strategies, in conjunction with humanized mouse models, our goals are to improve traditional organ transplantation outcomes, gain new insights into PSC biology and immunology, and enable curative regenerative medicine therapies.

Department Website

Latest Publications

Small-diameter artery grafts engineered from pluripotent stem cells maintain 100% patency in an allogeneic rhesus macaque model

Autologous vascular grafts, used for small-diameter revascularizations, face challenges such as invasive harvesting, limited availability, and variable quality. In this collaboration with lead author John Maufort at the Wisconsin National Primate Research Center, the research team developed a 3-mm-diameter artery graft using arterial endothelial cells (AECs) derived from pluripotent stem cells (PSCs). The AECs were seeded on a modified scaffold made from expanded polytetrafluoroethylene (ePTFE). Wild-type (WT) and first-generation hypoimmune (MHC knockout) cell grafts were transplanted in a rhesus arterial interposition grafting model. WT grafts showed 100% patency for 6 months, with repopulation of the endothelium by host cells, offering a promising solution for allogeneic arterial revascularization.

News & Events

Grad Student Offered GEM Ph.D. Engineering and Science Fellowship

Mireya Pimentel was offered the GEM Fellowship for Summer 2025. GEM offers MS and Ph.D. level students the ability to explore opportunities in industry and academia through access to dozens of the top Engineering and Science firms and Universities in the nation.

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Brown Lab Awarded Grant to Study Potential New Treatment for Type 1 Diabetes

With a new two-year grant from Breakthrough T1D, the leading global type 1 diabetes research and advocacy organization, Dr. Brown and his team will create and study hypoimmune, insulin-producing, stem cell-derived islet-like clusters as a potential new treatment for type 1 diabetes.

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WARF Features Dr. Matthew E. Brown in Inventor Profiles

The Wisconsin Alumni Research Foundation highlights Dr. Brown's work and goals for the future.

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Grad Student Takes on 2025 SURF Mentorship Role

Sayandeep Saha will mentor undergraduate Christopher DeCorte with a focus on functional characterization of

hypoimmune pluripotent stem cell-derived endothelial cells. The Summer Undergraduate Research Fellowship supports motivated University of Wisconsin–Madison undergraduate students as they pursue research in stem cell science and regenerative medicine.

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Contact Us

The Brown Lab is recruiting highly motivated postdocs, technicians, and undergraduate students. Dr. Brown is a trainer in the CBMS, MCP, CMP, and CMB graduate programs.

Join Our Team!