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Autologous vascular grafts, used for small-diameter revascularizations, face challenges such as invasive harvesting, limited availability, and variable quality. In this collaboration with lead author John Maufort at the Wisconsin National Primate Research Center, the research team developed a 3-mm-diameter artery graft using arterial endothelial cells (AECs) derived from pluripotent stem cells (PSCs). The AECs were seeded on a modified scaffold made from expanded polytetrafluoroethylene (ePTFE). Wild-type (WT) and first-generation hypoimmune (MHC knockout) cell grafts were transplanted in a rhesus arterial interposition grafting model. WT grafts showed 100% patency for 6 months, with repopulation of the endothelium by host cells, offering a promising solution for allogeneic arterial revascularization.